MDE605: Molecular Basis of diseases and drug resistance 6 credits (40-0-20)

Objectives

To provide an in-depth coverage of the importance of genetic defects in deseases.

Contents

Mendel's experiments, monohybrid and dihybrid cross; sexual vis-a-vis asexual reproduction; applications of chi square test; deviation from Mendelian segregation; linkage ; genetic map; Mendelism in Human Genetics: Pedigree analysis ; inheritance characteristics of sex-linked and autosomal traits; chromosomes as physical basis of inheritance; chromosome aberrations; Sex-linked deleterious genes; non- Mendelian inheritance; parental imprinting; anticipation; dynamic mutations and neurological abnormalities; dysgenic effect of medicine; cancer genetics;

Drug resistance testing: Importance of mutations and their rapid detections in clinics