BCH618: Bioinformatics 6 credits (40-0-20)

Objectives

To present an in-depth treatment of biological databases, sequence analysis and data mining tools important in the design of drugs, diagnostics, vaccines, understanding of pathologies, drug resistance, and in agricultural biotechnology.

Contents

Up-dates on developments in Bioinformatics and Computational Biology; GenBank; EMBL, DDBJ, PDB, TREMBL; ZINC, PLASMODB; Flybase, MGD, SGD, TIGR, ACEDB; etc. Bioinformatics resources at the NCBI, EBI, The Sanger Center, KEGG, ExPASY, SwissProt, UniProt, EMBOSS; etc. File formats, analysis of single DNA and Protein sequences, blast, primer and probe design, gene finding, sequence alignments, function predictions, phylogenetics, Epitope and HLA predictions, protein modelling, motifs, domains and family predictions, in silico molecular docking; Genomics, Genome sequencing methodologies, Proteomics and 2D gels, Transcriptomics and metabolomics; Internet laboratory sessions for teaching the databases and data mining tools.