Faculty of Science

Objectives

To provide an exhaustive treatment of the fundamental concepts of drug design, with special emphasis on mechanistic aspects of early strategies and contemporary approaches.

Contents

Molecular determinants of drug-target interactions; fundamental concepts in drug design including but not restricted to structure-activity relationships; receptor site theory; bioisosterism; enzyme kinetics and strategies of enzyme inhibition; anti-metabolite theory; receptor mapping and conformational restriction approaches; the pharmacophore concepts; molecular structure and drug disposition; pro-drug strategies, pharmacologic screening; lead identification and optimization strategies.