BCH708: Parasite Biochemistry 6 credits (40-10-10)

Objectives

To cover specific metabolic pathways in parasitic organisms that are targets for antiparasite chemotherapy. The possibilities for chemotherapeutic interventions will be emphasized.

Contents

Parasite proteinases and amino acid metabolism; Purine and Pyrimidine metabolism; Polyamine Metabolism; Lipid and membrane metabolism of the malaria parasite and African trypanosome; Antioxidant mechanisms; Xenobiotic metabolism; Neurotranmitters of Helminths and target sites of anthelminthics; Invasion mechanisms; Concepts of chemotherapy; Validating targets for antiparasite chemotherapy; Drug resistance mechanisms.